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I am a clinical pharmacist currently doing freelance writing on various pharmacy topics. I graduated from Arnold and Marie Schwartz School of Pharmacy in 1988 with a bachelors degree in pharmacy. While practicing as a clinical pharmacist I obtained my Doctor of Pharmacy degree (PharmD) from the University of Florida in 2003.

Wednesday, August 31, 2011

Alert: Drug Interaction Between Zocor®(simvastatin) and Norvasc®(amlodipine)

Alert: Drug Interaction Between Zocor®(simvastatin) and Norvasc®(amlodipine)
New alerts are bringing up questions about the interaction between simvastatin (Zocor®) and amlodipine (Norvasc®). The combination IS associated with a higher risk of myopathy. Myopathy is a muscular disease in which the muscle fibers do not function for any one of many reasons, resulting in muscular weakness. Healthcare practitioners should follow the new FDA guidelines and limit simvastatin (Zocor®) to 20 mg/day in patients taking amlodipine. Suggest switching patients who need simvastatin (Zocor®) 40 mg/day to pravastatin (Pravachol®) 80 mg, atorvastatin (Lipitor®) 20 mg, or rosuvastatin (Crestor®) 5 mg. Amlodipine isn't likely to significantly affect levels of these statins.

Source: Pharmacist's Letter

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